Enviar artigo por via de e-mail Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus
- Autores: Rodionov А.N.1, Snegur L.V.1, Simenel А.А.1, Dobryakova Y.V.2, Markevich V.А.2
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Afiliações:
- A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
- Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
- Edição: Volume 66, Nº 1 (2017)
- Páginas: 136-142
- Seção: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/239891
- DOI: https://doi.org/10.1007/s11172-017-1711-1
- ID: 239891
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Resumo
A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established
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Sobre autores
А. Rodionov
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991
L. Snegur
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Autor responsável pela correspondência
Email: snegur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991
А. Simenel
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991
Yu. Dobryakova
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Rússia, 5А ul. Butlerova, Moscow, 117485
V. Markevich
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Rússia, 5А ul. Butlerova, Moscow, 117485
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