电邮这篇文章 Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus
- 作者: Rodionov А.N.1, Snegur L.V.1, Simenel А.А.1, Dobryakova Y.V.2, Markevich V.А.2
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隶属关系:
- A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
- Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
- 期: 卷 66, 编号 1 (2017)
- 页面: 136-142
- 栏目: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/239891
- DOI: https://doi.org/10.1007/s11172-017-1711-1
- ID: 239891
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详细
A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established
作者简介
А. Rodionov
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991
L. Snegur
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
编辑信件的主要联系方式.
Email: snegur@ineos.ac.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991
А. Simenel
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
俄罗斯联邦, 28 ul. Vavilova, Moscow, 119991
Yu. Dobryakova
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
俄罗斯联邦, 5А ul. Butlerova, Moscow, 117485
V. Markevich
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
俄罗斯联邦, 5А ul. Butlerova, Moscow, 117485
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