Отправить статью по E-mail Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus
- Авторы: Rodionov А.N.1, Snegur L.V.1, Simenel А.А.1, Dobryakova Y.V.2, Markevich V.А.2
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Учреждения:
- A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
- Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
- Выпуск: Том 66, № 1 (2017)
- Страницы: 136-142
- Раздел: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/239891
- DOI: https://doi.org/10.1007/s11172-017-1711-1
- ID: 239891
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Аннотация
A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established
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А. Rodionov
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Россия, 28 ul. Vavilova, Moscow, 119991
L. Snegur
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Автор, ответственный за переписку.
Email: snegur@ineos.ac.ru
Россия, 28 ul. Vavilova, Moscow, 119991
А. Simenel
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Россия, 28 ul. Vavilova, Moscow, 119991
Yu. Dobryakova
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Россия, 5А ul. Butlerova, Moscow, 117485
V. Markevich
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences
Email: snegur@ineos.ac.ru
Россия, 5А ul. Butlerova, Moscow, 117485
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