Synthesis and biological activity of arylaliphatic  N -(2-aminoethyl)- N -(2-hydroxy-2-phenylethyl)carboxamides

D. Q. Hoang; E. Ya. Borisova; N. Yu. Borisova; N. Yu. Asilova; O. S. Kaldyrkaeva; E. V. Arzamastsev; O. A. Terekhova; E. Yu. Afanas’eva; E. L. Levitskaya

doi:10.1007/s11172-018-2048-0

Synthesis and biological activity of arylaliphatic N-(2-aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides

Autores: Hoang D.Q.¹, Borisova E.Y.¹, Borisova N.Y.¹, Asilova N.Y.¹, Kaldyrkaeva O.S.², Arzamastsev E.V.², Terekhova O.A.², Afanas’eva E.Y.², Levitskaya E.L.²
Afiliações:
1. Moscow Technological University (Institute of Fine Chemical Technology)
2. Russian Cardiology Research and Production Complex
Edição: Volume 67, Nº 1 (2018)
Páginas: 131-136
Seção: Article
URL: https://journal-vniispk.ru/1066-5285/article/view/241982
DOI: https://doi.org/10.1007/s11172-018-2048-0
ID: 241982

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Resumo

N-(2-Aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides were synthesized from styrene oxide by ring opening with N,N-disubstituted ethylenediamines followed by N-acylation. Synthesized compounds have pronounced antiarrhythmic activity and low toxicity.

Palavras-chave

styrene oxide, ethylenediamine, diamino alcohols, amino amides, acylation, arrhythmia, biological activity

Sobre autores

D. Hoang

Moscow Technological University (Institute of Fine Chemical Technology)

Autor responsável pela correspondência
Email: quanghoang1510@gmail.com
Rússia, 86 prosp. Vernadskogo, Moscow, 119571

E. Borisova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
Rússia, 86 prosp. Vernadskogo, Moscow, 119571

N. Borisova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
Rússia, 86 prosp. Vernadskogo, Moscow, 119571

N. Asilova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
Rússia, 86 prosp. Vernadskogo, Moscow, 119571