Changes in ovarian function in women of reproductive age after organ-sparing interventions on the pelvic organs

The objective. Changes in the function of the ovaries were evaluated in women of reproductive age after organ-sparing interventions on the pelvic organs. Patients and Methods. The study was carried out in 98 women of reproductive age with benign tumors of the pelvic organs (uterine myoma, ovarian cysts, tuboperitoneal sterility), who wished to remain fertile after the intervention. The patients ’ ages varied from 22 to 44 years (median 32.9 ± 0.5 years), 58 of them were operated on for the first time and 40 repeatedly. Significant differences were detected between the groups of patients after a single and repeated surgeries. Results. Hormonal analysis showed significantly higher concentrations of LH and FSH and lower levels of E2 and anti-Muller hormone 6 months after the operation, these shifts more pronounced after repeatedly operations. Echographic examination of the pelvic organs showed a significant shrinkage of the uterus and both ovaries and reduction of the follicular pool. Conclusion. Hence, the ovarian reserve underwent more profound changes with every new surgical intervention on the pelvic organs. Organ-sparing operations on the pelvic organs led to reduction of the follicular pool with the formation of preterm failure of ovarian function.

ovarian reserve, ovarian function, organ-sparing surgery, laparotomy, laparoscopy, mono- and bipolar electrosurgery